Paper Title
ADVANCED 3D BIOPRINTING OF MULTICOMPONENT BIOINK FOR EVEN TISSUE REGENERATION

Abstract
Abstract - The layer-by-layer deposition of 3D printing technique enables precise reconstruction of complex architecture. Cell embedded 3D printing or 3D bioprinting technology has been advanced to regenerate complex tissues. In this context, extrusion-based 3D bioprinting with multicomponent hydrogel bioink matrix is widely used by researchers to overcome the limitations of a single component. However, homogeneous mixing of different components with minimum damage on live cells is a challenge as inhomogeneity in mixing leads to uneven tissue formation. Our developed extrusion head is capable of simultaneous mixing and 3D bioprinting of multicomponent bioinks including bioactive nanocomposite hydrogels. Bioactive nanoparticles use in tissue engineering is increasing due to its reinforcing ability to improve post printing shape fidelity of the 3D bioprinted structure. Ensuring homogeneous distribution of all components used in an advanced bioink ensures even tissue regeneration in multilayered and complex tissue engineering process. Keywords - 3D Bioprinting, Hydrogel, Tissue Engineering.