A Study on Anti-Cancer Activity of Euphorbia Neriifolia (Milk Hedge) Latex
The study was carried out to evaluate antitumor activity of extracts of latex of Euphorbia neriifolia in validated experimental animal models. Antitumor activity of acetone extract was investigated against DLA induced ascites tumor in mice. Two doses 50 mg/kg and 100 mg/kg b.w p.o of the extract were subjected for the evaluation of Antitumor potential against DLA induced mice and Cyclophosphamide used as standard. The parameter percentage mortality was studied. Phytochemical study and Invitro cytotoxicity studies were also performed. It was observed that Both EN- 50 and EN- 100 showed dose dependent significant reduction in mortality rate and increased recovery in the extract treated mice when compared with vehicle control. Maximum protection was observed at 100mg/kg. Terpenoids were found to be the major component of acetone extract. The present study concluded that latex extract of Euphorbia neriifolia has significant antitumor potential. The exact mechanism for the antitumor activity of EN is still unknown hence further studies are needed to isolate, characterize the active principles and to find out the exact mechanism responsible for its antitumor activity.
Keywords - Tumor, Acetone, Cyclophosphamide, Euphorbia neriifolia.