Elevation of Glycated Hemoglobin (HBA1C) in Non-Diabetic Individuals, By Effect of Microcytic Hypochromic Anemia
Background: The affecting the erythrocyte normality will affect the concentration of HbA1c in the blood. Although many forms of anemia are associated with lowering of HbA1c, iron deﬁciency tends to increase HbA1c.
Objective: The aim of this study is to analyze the effects of iron deficiency anemia on HbA1c levels.
Materials and Methods: The study included 120 cases of non-diabetic patients who were diagnosed as having iron deficiency anemia and comparison to180 cases ofhealthy individuals. Estimation the HbA1c and absolute levels of HbA1c, for all cases in this study after confirmation that all cases have normal level of fasting blood sugar and don't have any history for diabetes. The data of the individuals attending Shree Krishna Hospital Karamsad, Anand between August 2015 to July 2017 was collected. The study was approved by an institutional ethics committee.
Results: The mean HbA1c level (6.5 ± 0.5%) in the iron deficiency anemia was higher than that the mean HbA1c level (5.4 ± 0.7%) in the control group. There were no significant differences in the levels of fasting and postprandial glucose between the IDA and the control groups (p > 0.05).
Conclusion: The microcytic hypochromic anaemia has an effect on the increased level of glycosylated hemoglobin (HbA1c), especially iron deficiency anemia. That the necessary intervention can be done by administration of iron. This helps to avoid misdiagnosis of diabetics, based on elevated the level of HBA1C, in patients with iron deficiency anemia.
Keywords - Iron deficiency anemia, ferritin, Hemoglobin A1c and non-diabetic patients.