Paper Title
DETERMINING THE ROLE OF ALOE-VERA DERIVED EXTRACELLULAR VESICLES IN DIABETIC WOUND HEALING

Abstract
Delayed wound healing are common complications for diabetic patients. Because chronic hypoxia delays wound healing making better oxygenic environment to wound site is hypothesized to promote diabetic wound healing. ELVs of Aloe barbadensis, Azadirachtaindica and Zingiberofficinale have wound healing properties because they oxygenate the extensive hypoxic environment at the wound site. Hence a powerful oxygenated combination therapy could be created by combining the oxygen delivering ELVs of different medicinal plants, Aloe barbadensis, Azadirachtaindica and Zingiberofficinalein the ratio 10: 0.5: 0.5 (ml) respectively (Oxy- ExoAloe). Till date no any study was done using medicinal plants in various combined proportion. Our study shows that these ancient medicinal herbs together increase the wound healing rate showing triple booster action and reduces the healing duration by half than any one of the alone studied. Release of oxygen from these herbs increased the survival of keratinocytes and dermal fibroblasts, promoted angiogenesis and decreased the pro-inflammatory cytokine expression. All these effects significantly increased the wound closure rate. Our finding demonstrate that Oxy- ExoAloe therapy promoted diabetic wound healing earlier through increasing re-epithelialization, sufficient oxygen supply making aerobic condition on wound site and angiogenesis. Keywords - Diabetes, ELVs, Oxy-ExoAloe, Wound healing