Paper Title
Evaluating Thrombogenic Risks of Bare Metal vs. Drug-eluting Stents: Insights from In Vitro Blood Flow Loop Studies

Abstract
This study aimed to evaluate the thrombogenic potential of bare metal stents in comparison to drug-eluting stents coated with Sirolimus and Everolimus, using a simplified blood flow loop model. Blood samples were obtained from an abattoir, and three experimental procedures were conducted: determining heparin concentrations, assessing thrombogenicity in vitro across three stent types, and measuring platelet and leukocyte counts in treated blood. The results showed that bare metal stents produced the highest thrombus formation, while Sirolimus-eluting stents demonstrated the lowest thrombosis risk, and Everolimus-eluting stents had moderate thrombogenicity. These findings underscore the importance of optimizing stent coatings to minimize the risk of stent thrombosis. Keywords - Stent, Flow Loop, Platelet, Stent Thrombosis.