Paper Title
Comparison of Immuno-Hematological Parameters Between Celiac Patients and Non-Celiac Individuals

Abstract
This study investigates the differences in immuno-hematological parameters between celiac patients and non-celiac individuals. Focusing specifically on variations in white blood cell profiles. Celiac disease, an autoimmune disorder triggered by gluten ingestion, is associated with a range of immunological conditions, yet the relationship between celiac disease and other autoimmune disorders, such as diabetes, anemia, osteoporosis and thyroid disorder, remains inadequately explored. Utilizing data from the UK Biobank, a comprehensive biomedical database, we analyzed a cohort of 3298 celiac patients identified through ICD10 coding, comparing them to a substantial population of 420870 non-celiac individuals. Our findings reveal significant alterations in the hematological parameters of the celiac patients, including notable differences in basophil percentage (p = 0.021), eosinophil percentage (p < 0.001), lymphocyte percentage (p < 0.001), and neutrophil percentage (p = 0.001). These results underscore the need for further investigation into the clinical implications of these immuno-hematological changes. Additionally, we recommend incorporating lifestyle factors and medical histories alongside immuno-hematological parameters to deepen our understanding of the correlations affecting celiac patients and their broader immune profiles. Keywords - Celiac Disease, Complete Blood Count, Immuno-Hematological, UK Biobank