Paper Title
Metronomic Chemotherapy: Changing the Approach that Bigger is always Better

Abstract
Conventional chemotherapy and even new drug delivery systems lead to adverse drug reactions that restrict dosing and interferes the efficacy of anti‑neoplastic drugs.So exploring new therapeutic targets as well as new therapeutic strategies are essential to improve cancer treatment. Metronomic chemotherapy is one such new modality of administering cytotoxic drugs. Metronomic chemotherapy involves frequent administration of conventional chemotherapeutic agents at very low doses to target activated endothelial cells in tumors without any drug free break.In addition to reduced acute toxicity, the efficacy of metronomic chemotherapy seems to increase when administered in combination with specific anti-angiogenic drugs. Keywords - Anti-angiogenesis, Cancer, Chemotherapy, Metronomic.