Increased Levels of Homocysteine in T2DM Correlated with Glycated Hemoglobin and HDL-C
Background: An increased level of homocysteine (Hcy) in blood is associated with the development of cardiovascular diseases (CVD) and leads to morbidity and mortality in T2DM. Objectives: To investigate the relation between homocysteine, age, HbA1c and HDL-C in patients with T2 diabetes mellitus (T2DM). Materials and methods: The expression of inflammatory marker like homocysteine, glycemic control marker such as HbA1c and serum levels of HDL-C were determined in 100 T2DM patients compared with 100 healthy controls. Homocysteine was measured by enzymatic colorimetric method, HbA1c was estimated by immunoturbidimetry and Serum HDL-C was estimated by precipitation method. Results: Significant difference was observed in mean levels of age, FBS, BMI, HbA1C, Cholesterol, TGL,HDL-C and Hcy of T2DM patients when compared with controls (p<0.05). Hcy was positively correlated with age, HbA1c and negatively correlated with HDL-C (p<0.05). Conclusion: Raised levels of Hcy associated with increased levels of HbA1c and lowered levels of HDL-C and these altered parameters could contributed to development of CVD among T2DM patients.
Keywords - T2 DM, Cardiovascular Diseases, Stroke, Homocysteine, Glycated Hemoglobin and HDL-C.