Paper Title
A Study of Thrombocytopenia and Aki in Malaria Patients

Abstract
Background: Malaria is a major health problem in many parts of India. It has varied manifestations and it is imperative for us to know the laboratory features of malaria along with clinical presentations. Objective: To study the incidence of thrombocytopenia andAKI in malaria cases. Methods: This is a retrospective study of malaria cases conducted at S. Nijalingappa Medical College and HSK Hospital and Research Centre, Bagalkot. Results: In this study, among 103 patients, 71 are males and 32 females. In this 40(38.8%) are among age group 15-30 years, 30 (29.1%) belong to 31-50 years age group, 26 (25.2%) among age group 51-70 and 7 (6.7%) are age group more than 71.Malaria is most common during the month of July 20 cases (19.4%) and August 19 cases (18.43%). Out of 103 patients 61 (59.1%) had infection with P.vivax, 23 (22.3%) had infection with P.falciparum and mixed infection in 19(18.4%). A total of 60 cases in our study have thrombocytopenia, 16 (15.52%) cases have platelet count less than 20,000, 19 (18.43%) have platelet count 21,000-50,000, 25 (24.25%) cases have platelet count 51,000-1,50,000. Severe thrombocytopenia is seen in 3(2.91%) cases of Plasmodium vivax infection, 4 (3.88%) cases of Plasmodium falciparum infection and 7(6.97%)cases of mixed infection. Among 103 cases we noted an increase in serum creatinine value in 22 cases, 16 (15.52%) cases are due to Plasmodiumvivax, 4 (3.88%) cases are due to Plasmodium falciparum and 2 (1.94%) cases have mixed infection Conclusion: Our study describes various intensity of thrombocytopenia and AKI in malaria patients. Thus by being more alert and knowing the different presentations and lab features of this common disease early diagnosis can be made which in turn would help us for better treatment thus reducing the morbidity and mortality associated with it. Malaria can present as a benign illness or with significant morbidity and mortality. Along with clinical features we need to keep haematological manifestations in to consideration, this can identify early organ involvement irrespective of infection caused by vivax, falciparum and/or mixed infection malaria. Keywords - Malaria, Thrombocytopenia, AKI.