Paper Title
Evidence of Nephroprotective as well as Neuroprotective Effect of Garcinia Pedunculata Roxb. Ex Buch.-Ham Extracts in Chronic Kidney Disease Mouse Model

The progressive loss of kidney function affects a substantial population globally. The prevalence of various factors like diabetes, high blood pressure, and cardiovascular diseases accelerate the gradual loss of kidney functions. With the increasing prevalence of these diseases amongst the Indian population, the prevalence of chronic kidney disease (CKD) is also on the rise. In India, the approximate incidence of CKD is 800 per million population. CKD is a common ailment often associated with neurological complications get worsens over time. In our study, high adenine nourishment advances to CKD with hyperuricemia, and the accumulation of uroliths of adenine and 2, 8-dihydroxyadenine are validated in mice model. The present study was carried out to unveil the nephroprotective as well as neuroprotective abilities of aqueous fruit extract of Garcinia pedunculata (2% w/v mixed with drinking water) in an animal model of CKD and associated complications. The mice were provided with enriched adenine (0.3% w/w) feed mixed with feed to develop the CKD model. An increase in the levels of uric acid, serum urea, and histopathological changes in the kidney was considered as parameters to validate the model. Fruit water extract of G. pedunculata (GPE) considerably improved the serum levels of urea, uric acid, and histological changes of CKD mice. Interestingly, the administration of GPE also significantly ameliorated CKD associated complications of cognitive impairment and brain acetylcholinesterase (AChE) activity in mice. Therefore, the present study is significant in the therapy of CKD associated complications as a whole, and urolithiasis and hyperuricemia in particular. Keywords - Nephroprotective Effect, Neuroprotective Effect, 2, 8-Dihydroxyadenine, Hyperuricemia, Urolithiasis, Acetylcholinesterase