Paper Title
Study of Serum High Sensitivity C-Reactive Protein, Ferritin, Insulin, C-Peptide and Glycated Hemoglobin in Patients With Type 2 Diabetes Mellitus

Abstract
Background: Inflammation plays a major role in pathogenesis and progression of accelerated atherosclerosis in individuals with type 2 diabetes mellitus. Hence, the evaluation of inflammatory novel biomarkers like high-sensitivity C-reactive protein and ferritin serves as tools for cardiovascular risk prediction. Glycemic control is closely associated with cardiovascular complications in diabetes. Objectives: To evaluate the levels of high-sensitivity C-reactive protein, ferritin, insulin, C-peptide & glycatedhemoglobin in controls and type 2 diabetic subjects and to assess the correlations if any, between fasting serum glucose, high-sensitivity C-reactive protein, ferritin & glycatedhemoglobin. Materials and Methods: A total number of 100 subjects were studied, comprising of 50 controls and 50 type 2 diabetic subjects. Diabetic subjects were further divided depending upon treatment modalities. Serum levels of High-sensitivity C-reactive protein (hs-CRP), ferritin, insulin and C-peptide were measured by Chemiluminiscence immunoassay and blood glycatedhemoglobin (HbA1c) was measured by Nephelometry. The statistical analysis was carried out using Students’t’ test and Karl Pearson’s Coeffient of correlation. Results: High-sensitivity C-reactive protein, ferritin, insulin and glycatedhemoglobin levels were found to be significantly increased (p <0.001) in type 2 diabetic subjects as compared to controls. C-peptide level was found to be increased in type 2 diabetic subjects as compared to controls and the increase was not statistically significant. There was highly significant (p <0.001) positive correlations existed between fasting serum glucose, hs-CRP and HbA1c. Discussion & Conclusion: Glycatedhemoglobin serves as a simple and rapid procedure to assess glycemic control in type 2 diabetic subjects. Elevated levels of hs-CRP and ferritin predict the future cardiovascular complications in type 2 diabetic subjects. The current study demonstrates that higher HbA1c level significantly associated with elevation of hs-CRP. These results imply a significant relation between inflammation and glycemic control.