Paper Title
Polymer Based Advanced Miniaturized and Cost-Effective Point of Care Device For Diabetes Patients Detecting Glycated Albumin (GA)

Abstract
Long-term hyperglycemia can produce serious problems such as retinopathy, cardiovascular disease and neuropathy all of which can have a negative impact on the patients' lives [1, 2]. As a result, it is critical to detect diabetes at an early stage and take steps to control blood sugar and keep it within a normal range [1]. Earlier diagnosis of diabetes is a complex and painful process in conventional method FBS (Fasting Blood Sugar) that requires at least eight hours of fasting, patient wait for a longer period of time makes very tedious and patient suffer a lot due to multiple time blood sample required. HbA1c test is accurate and effective in overcoming this problem because it does not require any specific preparation such as fasting and is unaffected by exercise or stress. HbA1c indicates the average blood glucose level over the previous two to three months. However, HbA1C has its own limitations when it comes to certain clinical conditions that can interfere with haemoglobin metabolisms, such as hemolytic, secondary, or iron deficiency anaemia, haemoglobin opathies, pregnancy, and uremia, so it's not recommended[3]. The aim of this research is to develop a cost-effective and electrochemical biosensor for specific diabetic patient. The electrode was modified specifically for GA with synthesised Polymer Metrix the 3 D Matrix polymeric extremely specific to biomolecule provides great selectivity and sensitivity on the electrode surface also cost-effective [1]. MoS2 is an appealing choice for producing electrochemical biosensors because of its increased surface area, superior optical absorption, and great flexibility, as well as its excellent electrical and catalytic activity. Pt NPs offer biocompatibility, nonflammability, excellent chemical and thermal stability, and high ionic conductivity. It exhibits, Low detection limit as 0.34 nM and a wide detection range as 0.34 to 35x103 nM and 200 to 700 µM. Using a minimum sample of blood for detection, and miniaturized size makes it portable and the stability of this biosensor makes it an excellent point of care device for diagnosis. Keywords - FBSFasting Blood Sugar),HbA1CGlycated haemoglobin, GAGlycated Albumin, MoS2Molybdenum disulfide, Pt NPsPlatinum nanoparticles, µMMicromolar, nMNanomolar