Paper Title
Identifying the Glycated Hemoglobin (HBA1C) in Diabetes Patients with Advanced Miniaturized and Cost-Effective Polymeric-Based Biosensor
Abstract
Diabetic patients linked to a high risk of morbidity and mortality as a result of many associated problems. Earlier identification of diabetes is complex and painful process require at least 8 hours of fasting that makes a patient wait for longer time without any meal so in the morning to afternoon it's able to perform and the blood sample is taken for multiple times to diagnose makes patient suffer. The formation of HbA1c Complex is directly proportional to blood glucose levels. Average red blood cell life of 120 days thus glycosylated haemoglobin level reflects the average blood glucose level during the previous 2 to 3 months. This HbA1c point-of-care testing offers cost effective and quick diagnosis results immediate therapy modifications with time and it has been shown an improved glycemic control. The goal of this research is to develop a cost-effective and electrochemical biosensor. The electrode was modified specific for HbA1c with synthesised Polymer Metrix the 3 D Matrix polymeric extremely specific to biomolecule provide great selectivity and sensitivity on the electrode surface also cost effective [1]. Incorporation of Fe3O4Nanoparticles help to enhance the surface area of the electrode, which improves electron transport and hence increases the electrode's conductivity [2].It exhibits a wide detection range from 1 pM to 1x105 pM and a lower detection limit. Require a minimum sample of blood for detection, miniaturized size makes it portable and the stability of this biosensor makes it an excellent point of care device for diagnosis.
Keywords - FBSFasting Blood Sugar),HbA1CGlycated haemoglobin,Fe3O4 Iron(II, III) oxide, µMMicromolar, pMPicomolar