Paper Title
Design and Development of Metallic Nanoparticles (NPs) based Drug Delivery Model Against Cancer

Abstract
Zinc nanoparticles and silver nanoparticles were successfully synthesized and their characterization was done. A comparison with the green synthesis method and the chemical synthesis method was done. For green synthesis of silver and zinc nanoparticles, two medicinal plants were used having anti cancer, anti fungal, anti tumour and anti microbial properties. They were collected from the outskirts of campus, Ranchi. Capping agent was used during the chemical synthesis of metal nanoparticles. Cancer cells are well known in the scientific community as they can obtain genetic mutation over time which changes the cells’ behaviour pattern and mode of action. These complexities and heterogenicity of cancer cells destabilize and compromise the therapeutic potential of treatment. Therefore, inclination in clinical research can be observed of shifting from monotherapy to nano-therapy that can enhance the efficiency of cancer treatment manifold. Metal oxide nanoparticles (MONPs) such as zinc oxide nanoparticles (ZnO NPs) and silver nanoparticles (Ag NPs) show selective cytotoxicity against tumor cells through the generation of reactive oxygen species (ROS).Tiny size of NPs can achieve a prolonged residence time inside living bodies. The desired drug-release pattern can also be controlled by the size and architecture of nanoparticles. In silico study was done by designing the structure of metal nanoparticles using the Avogadro software, it isan open-source computational chemistry tool widely used to model chemistry systems and 3D structure of mNPs. Antimircobial activity was checked in all these nanoparticles samples. The mNPs have the potential to be incorporated in cells to work against cancer cells and inhibit their growth. Keywords - Nanotheranostics, Green synthesis, Zinc nanoparticles, Chemical synthesis